Which individual must contact the Speaker of the House and the President Pro Tempore regarding presidential incapacity?

The correct response is the majority of department secretaries. According to the 25th Amendment of the U.S. Constitution, when there is a question regarding a president's ability to fulfill their duties, the vice president and a majority of the cabinet secretaries can notify the Speaker of the House and the President Pro Tempore of the Senate. This process is designed to ensure that if the president is incapacitated, there is a clear protocol for the transfer of power, allowing the vice president to assume the role of acting president.

The role of the Chief Justice involves presiding over presidential impeachment cases, but it does not include contacting congressional leaders regarding presidential incapacity. Similarly, while the Vice President plays an important role in this context, they alone do not have the authority to make such a notification without the majority of the cabinet. The National Security Advisor, while an important advisor to the president, does not have a formal role in this process either. Understanding this constitutional framework is crucial for grasping the mechanisms of presidential succession and the responsibilities assigned to various officials in scenarios of presidential incapacity.